Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation

Title:Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation

Volume: 16 Issue: 1

Author(s): Sanath Kumar, Guixin He, Prathusha Kakarla, Ugina Shrestha, Ranjana KC, Indrika Ranaweera, T. Mark Willmon, Sharla R. Barr, Alberto J. Hernandez and Manuel F. Varela

Affiliation:

Keywords: Antimicrobial agents, bacterial pathogens, drug targets, efflux pump modulation, infection, major facilitator superfamily, multidrug resistance.

Abstract: Causative agents of infectious disease that are multidrug resistant bacterial pathogens represent a serious public health concern due to the increasingly difficult nature of achieving efficacious clinical treatments. Of the various acquired and intrinsic antimicrobial agent resistance determinants, integral-membrane multidrug efflux pumps of the major facilitator superfamily constitute a major mechanism of bacterial resistance. The major facilitator superfamily (MFS) encompasses thousands of known related secondary active and passive solute transporters, including multidrug efflux pumps, from bacteria to humans. This review article addresses recent developments involving the targeting by various modulators of bacterial multidrug efflux pumps from the major facilitator superfamily. It is currently of tremendous interest to modulate bacterial multidrug efflux pumps in order to eventually restore the clinical efficacy of therapeutic agents against recalcitrant bacterial infections. Such MFS multidrug efflux pumps are good targets for modulation.

Cite this article as:

Kumar Sanath, He Guixin, Kakarla Prathusha, Shrestha Ugina, KC Ranjana, Ranaweera Indrika, Mark Willmon T., R. Barr Sharla, J. Hernandez Alberto and F. Varela Manuel, Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation, Infectious Disorders - Drug Targets 2016; 16 (1) . https://dx.doi.org/10.2174/1871526516666160407113848