Generic placeholder image

Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)


ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Synthesis and Biological Activity of 3-(substitutedphenyl)- 6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

Author(s): Niranjan Kaushik, Nitin Kumar and Anoop Kumar

Volume 16, Issue 1, 2016

Page: [70 - 80] Pages: 11

DOI: 10.2174/1871522216999160406125836

Price: $65


A new series of triazole containing thiadiazine moiety have been synthesized and characterized. All the new compounds were assayed for their in vitro antioxidant activity by DPPH free radical scavenging method and in vivo anti-diabetic activity by streptozotocin-induced model in albino rat. Anticancer activity of synthesized compounds was performed at the National Cancer Institute (NCI) on NCI 60 cell lines panel. Among the synthesized compounds, 2d exhibited more prominent antioxidant activity with IC50 value 16.97 g/ml, 59.15% blood glucose lowering activity and moderate anticancer activity with 44.59% growth inhibition against CCRF-CEM (Leukemia) cell lines. Compounds 2e and 2j showed good antioxidant activity with IC50 value 21.40 and 18.78 g/ml. Compounds 2b and 2e showed significant 59.98 and 48.44% blood glucose lowering activity.

Keywords: Anticancer activity, anti-diabetic activity, antioxidant activity, streptozotocin, thiadiazine, thiocarbohydrazide, triazole.

« Previous
Graphical Abstract

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy