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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Endoplasmic Stress Inhibitors for Homocysteine Induced Cardiovascular Disease

Author(s): Anthony Zulli

Volume 22, Issue 18, 2016

Page: [2704 - 2708] Pages: 5

DOI: 10.2174/1381612822666160406121342

Price: $65


Cardiovascular disease (CVD) remains a major cause of death and disability worldwide, thus preventing and inhibiting CVD remains a health priority. Several lines of pharmacological interventions have not met with great success, thus inhibition of novel cellular stress pathways could be a novel therapeutic avenue to treat CVD. This review will focus on homocysteine and endoplasmic reticulum stress linked to mitochondria function, and possible therapeutic avenues for treatment.

Keywords: Endoplasmic reticulum stress, endothelial function, homocysteine, atherosclerosis, taurine, Nox.

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