摘要
基于类异戊二烯应力相关的植物激素脱落酸(ABA)最近被认为在哺乳动物中传递了多方面的生物学功能,在许多临床相关的人类疾病中发挥了一定的疗效。人体标本研究已经明确表明,ABA保留了其与压力相关的功能属性,在植物中首先被确定,这有助于增强哺乳动物的炎性防御机制。此外,在动物模型中进行的研究显示,ABA显著的抗炎性能在浸润在炎症细胞中的免疫细胞中显著的降低了。因此,脱落酸的治疗最终导致了非传染性和传染性疾病的深远改善,与整体缓解炎症反应密不可分。除了其在哺乳动物免疫系统中的作用,脱落酸还在非免疫组分中发挥着不同的生理功能。其中最显著的特点是刺激和扩大间充质干细胞,这可能会打开一个新的纪元关于再生医学领域中的潜在用途。而且,ABA已被报道在血糖控制的维持中起着重要的作用。在这篇文章中,我们总结了当前脱落酸在哺乳动物中的重要性,其在各种疾病的设定和未来的发展方向中的前景,脱落酸作为新的候选药物的炎症和感染性人类疾病的治疗。
关键词: 脱落酸;植物激素;非传染性疾病;传染性疾病;干细胞;抗炎剂。
Current Medicinal Chemistry
Title:Abscisic Acid: A Phytohormone and Mammalian Cytokine as Novel Pharmacon with Potential for Future Development into Clinical Applications
Volume: 23 Issue: 15
Author(s): Priya Sakthivel, Niharika Sharma, Philipp Klahn, Marcus Gereke, Dunja Bruder
Affiliation:
关键词: 脱落酸;植物激素;非传染性疾病;传染性疾病;干细胞;抗炎剂。
摘要: The isoprenoid stress-associated phytohormone abscisic acid (ABA) has recently been recognized to possess multifaceted biological functions in mammals and to exert potent curative effects in a number of clinically relevant human diseases. Studies with human specimens have unequivocally shown that ABA retains its stress-related functional attributes, previously identified in plants, which contribute to enhanced inflammatory defense mechanisms in mammals. Besides, studies performed in animal models revealed prominent anti-inflammatory properties of ABA as indicated by a marked reduction of immune cell infiltrates at the sites of inflammation. Thus, ABA treatment ultimately leads to the profound improvement of both non-communicable and communicable diseases which are associated with an overall alleviated course of inflammation. In addition to its action on the mammalian immune system, ABA was also shown to exert diverse physiological functions on non-immune components. One of the most remarkable features of ABA is to stimulate and expand mesenchymal stem cells, which may open a new avenue for its potential use in the field of regenerative medicine. Furthermore, ABA has been reported to play an important role in the maintenance of glycemic control. In this review, we summarize current understanding of the significance of ABA in the mammalian system, its prophylactic and therapeutic effects in various disease settings and the future directions for the development of ABA as novel drug candidate for the improved treatment of inflammatory and infectious human diseases.
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Priya Sakthivel, Niharika Sharma, Philipp Klahn, Marcus Gereke, Dunja Bruder , Abscisic Acid: A Phytohormone and Mammalian Cytokine as Novel Pharmacon with Potential for Future Development into Clinical Applications, Current Medicinal Chemistry 2016; 23 (15) . https://dx.doi.org/10.2174/0929867323666160405113129
DOI https://dx.doi.org/10.2174/0929867323666160405113129 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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