Abstract
The repair of musculoskeletal tissues has posed a constant challenge for orthopaedic surgeons, and the occurrence of bone and cartilage injuries is expected to increase with the aging of the world population. To overcome the limitations of current treatments, tissue engineering enhanced through gene therapy is garnering significant interest as a promising new alternative. This paper reviews the essential factors involved in tissue engineering, including the appropriate cell source, inductive agents, scaffolds, and mechanical stimulation. Particular emphasis is placed on the use of muscle-derived stem cells that can be genetically engineered to deliver growth factors to the site of injury and initiate the formation of new bone and cartilage. These same gene-carrying cells may also serve as a source of progenitor cells for bone and cartilage formation, making muscle-based gene therapy and tissue engineering a potential treatment for cartilage and bone defects.
Keywords: tissue engineering, gene therapy, mdsc, bone, cartilage, bmps
Current Genomics
Title: Muscle-Based Gene Therapy and Tissue Engineering for Cartilage and Bone Healing
Volume: 5 Issue: 1
Author(s): K. Corsi, G. H. Li, H. Peng and J. Huard
Affiliation:
Keywords: tissue engineering, gene therapy, mdsc, bone, cartilage, bmps
Abstract: The repair of musculoskeletal tissues has posed a constant challenge for orthopaedic surgeons, and the occurrence of bone and cartilage injuries is expected to increase with the aging of the world population. To overcome the limitations of current treatments, tissue engineering enhanced through gene therapy is garnering significant interest as a promising new alternative. This paper reviews the essential factors involved in tissue engineering, including the appropriate cell source, inductive agents, scaffolds, and mechanical stimulation. Particular emphasis is placed on the use of muscle-derived stem cells that can be genetically engineered to deliver growth factors to the site of injury and initiate the formation of new bone and cartilage. These same gene-carrying cells may also serve as a source of progenitor cells for bone and cartilage formation, making muscle-based gene therapy and tissue engineering a potential treatment for cartilage and bone defects.
Export Options
About this article
Cite this article as:
Corsi K., Li H. G., Peng H. and Huard J., Muscle-Based Gene Therapy and Tissue Engineering for Cartilage and Bone Healing, Current Genomics 2004; 5 (1) . https://dx.doi.org/10.2174/1389202043490005
DOI https://dx.doi.org/10.2174/1389202043490005 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Recent Progresses on The Improved Therapy of Melanoma by Novel Drug Delivery Systems
Current Drug Targets Cytotoxicity Studies of Curcumin Loaded-cockle Shell-derived Calcium Carbonate Nanoparticles
Nanoscience & Nanotechnology-Asia Understanding and Targeting Osteoclastic Activity in Prostate Cancer Bone Metastases
Current Molecular Medicine Natural Compounds as Antagonists of Canonical Wnt/β-Catenin Signaling
Current Chemical Biology Subcellular Detection and Localization of the Drug Transporter P-Glycoprotein in Cultured Tumor Cells
Current Protein & Peptide Science The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy
Current Medicinal Chemistry The Relationship between Pharmacological Properties and Structure- Activity of Chrysin Derivatives
Mini-Reviews in Medicinal Chemistry Down-Regulation of Notch1 Expression is Involved in HL-60 Cell Growth Inhibition Induced by 4-Hydroxynonenal, a Product of Lipid Peroxidation
Medicinal Chemistry Recent Patents Relating to Tumor Suppressor Genes
Recent Patents on DNA & Gene Sequences Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin
Current Medicinal Chemistry - Anti-Cancer Agents Liposomes: Targeted and Controlled Delivery System
Drug Delivery Letters From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Double Point Modified Analogs of Vitamin D as Potent Activators of Vitamin D Receptor
Current Pharmaceutical Design CYP24A1 as a Potential Target for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry The Phosphoinositide Signal Transduction Pathway in the Pathogenesis of Alzheimer’s Disease
Current Alzheimer Research Ellipticines as DNA-Targeted Chemotherapeutics
Current Medicinal Chemistry The Parathyroid Hormone Receptorsome and the Potential for Therapeutic Intervention
Current Drug Targets The Urokinase-type Plasminogen Activator and the Generation of Inhibitors of Urokinase Activity and Signaling
Current Pharmaceutical Design Heterocyclic Drug-polymer Conjugates for Cancer Targeted Drug Delivery
Anti-Cancer Agents in Medicinal Chemistry Extracellular Signals for Guiding Mesenchymal Stem Cells Osteogenic Fate
Current Stem Cell Research & Therapy