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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity

Author(s): Xiaoke Guo, Weilin Chen, Haopeng Sun and Qidong You

Volume 16 , Issue 16 , 2016

Page: [1843 - 1854] Pages: 12

DOI: 10.2174/1568026616666160315142647

Price: $65


Atrial fibrillation (AF) is one of the common arrhythmias that threatens human health and brings a huge burden to society. Current treatments of AF possess limited efficacy and considerable risks, so a lot of efforts have been made to develop new AF therapies. Kv1.5 potassium channel is considered as an efficacious and safe therapeutic target of AF for its selective existence in atrium. This review will give a brief profile of Kv1.5 potassium channel and describe the progress of Kv1.5 inhibitors in this decade from nonselective drugs to selective agents. The final section will discuss the advantages and disadvantages between selectivity and non-selectivity.

Keywords: Atrial fibrillation; IKur, Kv1.5, Multiple ion channel inhibitor, Nonselective inhibitor, Selective Kv1.5 inhibitor.

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