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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis

Author(s): James McNamara and Teresa Ann Murray

Volume 13, Issue 9, 2016

Page: [996 - 1005] Pages: 10

DOI: 10.2174/1567205013666160314150136

Price: $65


Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a pathogen-based etiology of AD.

Keywords: Alzheimer’s disease, beta amyloid, cell cycle reentry, herpes simplex virus, HSV1, tau pathology.

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