Abstract
Antibody-mediated rejection (AMR) is relatively uncommon in AB0-compatible liver grafts; however, recent data suggest that antibody-mediated mechanisms may play a role in the differential pathogenesis of liver graft rejection. In this sense, it has been shown that staining for diffuse C4d deposition (in endothelium or stroma of portal tracts or sinusoids) could be used as a tissue biomarker of humoral allograft rejection and fibrosis in biopsies obtained in post-transplantation period, in addition to the determination of donor specific antibodies (DSA). Therefore, more stringer criteria have to be established in order to define real antibody-mediated injury (acute rejection, chronic rejection or fibrosis development) in liver graft transplant. These criteria should intend to correlate allograft dysfunction associated with compatible histological findings, presence of DSAs and C4d positivity and should be clarified with respect to rejection injury frequency, its severity and its response to antibody-depleting immunosuppression in the future. This could improve our progressive understanding of the clinical-pathological characteristic and diagnostic approaches of AMR and fibrosis.
Keywords: Humoral response, alloantibodies, HLA, acute rejection, tolerance, liver transplant, fibrosis.
Current Protein & Peptide Science
Title:Humoral Response in Liver Allograft Transplantation: A Review of the Role of Anti-Human Leukocyte Antigen (HLA) Antibodies
Volume: 17 Issue: 8
Author(s): Manuel Muro, María R. Moya-Quiles and Anna Mrowiec
Affiliation:
Keywords: Humoral response, alloantibodies, HLA, acute rejection, tolerance, liver transplant, fibrosis.
Abstract: Antibody-mediated rejection (AMR) is relatively uncommon in AB0-compatible liver grafts; however, recent data suggest that antibody-mediated mechanisms may play a role in the differential pathogenesis of liver graft rejection. In this sense, it has been shown that staining for diffuse C4d deposition (in endothelium or stroma of portal tracts or sinusoids) could be used as a tissue biomarker of humoral allograft rejection and fibrosis in biopsies obtained in post-transplantation period, in addition to the determination of donor specific antibodies (DSA). Therefore, more stringer criteria have to be established in order to define real antibody-mediated injury (acute rejection, chronic rejection or fibrosis development) in liver graft transplant. These criteria should intend to correlate allograft dysfunction associated with compatible histological findings, presence of DSAs and C4d positivity and should be clarified with respect to rejection injury frequency, its severity and its response to antibody-depleting immunosuppression in the future. This could improve our progressive understanding of the clinical-pathological characteristic and diagnostic approaches of AMR and fibrosis.
Export Options
About this article
Cite this article as:
Muro Manuel, Moya-Quiles R. María and Mrowiec Anna, Humoral Response in Liver Allograft Transplantation: A Review of the Role of Anti-Human Leukocyte Antigen (HLA) Antibodies, Current Protein & Peptide Science 2016; 17 (8) . https://dx.doi.org/10.2174/1389203717666160226145101
DOI https://dx.doi.org/10.2174/1389203717666160226145101 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin
Recent Patents on Inflammation & Allergy Drug Discovery Age-related Vascular Differences among Patients Suffering from Multiple Sclerosis
Current Neurovascular Research Out-of-Hospital Cardiac Arrest –Optimal Management
Current Cardiology Reviews The Emerging Role of Histology in the Choice of First-Line Treatment of Advanced Non-Small Cell Lung Cancer: Implication in the Clinical Decision-Making
Current Medicinal Chemistry Do Antiphospholipid Antibodies Have Direct Pathologic Effects Upon Endometrial and Trophoblast Cells?
Current Rheumatology Reviews Current Management and Treatment of Cerebral Vasospasm Complicating SAH
CNS & Neurological Disorders - Drug Targets Role of Renin-Angiotensin System in Vascular Endothelial Dysfunction of Pregnancy-Induced Hypertension
Current Hypertension Reviews Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine
Mini-Reviews in Medicinal Chemistry Targeting Dyslipidemia in the Metabolic Syndrome: An Update
Current Vascular Pharmacology Potential Genetic Therapies for Acute Lung Injury
Current Gene Therapy Blind Snipers: Relevant Off Target Effects of Non-chemotherapeutic Agents in Oncology: Review of the Literature
Reviews on Recent Clinical Trials Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome
Current Pharmaceutical Design Editorial (Thematic Issue: Overview of Immunotherapy in Alzheimer’s Disease (AD) and Mechanisms of IVIG Neuroprotection in Preclinical Models of AD)
Current Alzheimer Research Biomarkers Determining Cardiovascular Risk in Patients with Kidney Disease
Current Medicinal Chemistry Capsaicin-Sensitive Nociceptive Innervation of the Dura Mater: Implications for the Pathomechanism of Headache
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Malondialdehyde and Superoxide Dismutase in High-dose Calcium Supplemented Women in Relation to Iron and Calcium Panels
Current Nutrition & Food Science The Physiological Basis and Nutritional Function of Alpha-ketoglutarate
Current Protein & Peptide Science Risk Factors for Heart Failure Progression and Outcomes
Current Cardiology Reviews Injecting Illicit Substances Epidemic and Infective Endocarditis
Infectious Disorders - Drug Targets Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry