Review Article

The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems

Author(s): Aleksandra Rutkowska, Kumlesh K. Dev and Andreas W. Sailer

Volume 17, Issue 16, 2016

Page: [1851 - 1860] Pages: 10

DOI: 10.2174/1389450117666160217123042

Price: $65

Abstract

Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor’s role in the adapted immunity and inflammation as well as the receptor’s expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.

Keywords: Astrocytes, autoimmunity, central nervous system, EBI2, immune system, neurodegeneration, oligodendrocytes.

Graphical Abstract

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