Abstract
Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkholderia cepacia complex and especially Pseudomonas aeruginosa are more frequently seen. P. aeruginosa is a turning point in the respiratory disease in CF and its predominance increases with age. Bacteria use a variety of two-component systems (TCS) to differentially express virulence factors involved in both acute and chronic infections. Here, we review bacterial TCS as targets for antibacterial treatment for CF patients.
Keywords: Bacterial infections, cystic fibrosis, two-component systems, antibacterial treatment, respiratory infection, pathogen.
Current Drug Targets
Title:Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients
Volume: 18 Issue: 6
Author(s): Nadya Velikova*Jerry M. Wells
Affiliation:
- Host-microbe Interactomics Group, Department of Animal Sciences, Wageningen University, Wageningen,Netherlands
Keywords: Bacterial infections, cystic fibrosis, two-component systems, antibacterial treatment, respiratory infection, pathogen.
Abstract: Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkholderia cepacia complex and especially Pseudomonas aeruginosa are more frequently seen. P. aeruginosa is a turning point in the respiratory disease in CF and its predominance increases with age. Bacteria use a variety of two-component systems (TCS) to differentially express virulence factors involved in both acute and chronic infections. Here, we review bacterial TCS as targets for antibacterial treatment for CF patients.
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Cite this article as:
Velikova Nadya*, Wells M. Jerry, Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients, Current Drug Targets 2017; 18 (6) . https://dx.doi.org/10.2174/1389450117666160208145934
DOI https://dx.doi.org/10.2174/1389450117666160208145934 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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