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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Possible Role of Cancer Stem Cells in Colorectal Cancer Metastasizing to the Liver

Author(s): Zuo-Yi Jiao, Hong-Tai Cao and Yu-Min Li

Volume 11, Issue 5, 2016

Page: [440 - 443] Pages: 4

DOI: 10.2174/1574888X11666160201115840

Price: $65


Colorectal cancer (CRC) is one of the most common cancers in the world. In recent decades, drug therapy and surgery have not achieved satisfactory results in curing CRC. The identification of cancer stem cells (CSCs) has provided a possible mechanistic explanation of CRC growth and metastasis. Traditional chemotherapy targets rapidly dividing cells, and since the CSCs can escape these therapies and become circulating cells, CSCs may be responsible for cancer relapse and metastasis. A better understanding of the roles of CSCs in the pathogenesis of primary CRC and its metastasis, as well as how these CSCs are regulated at the molecular level, is of paramount importance. In this review, we summarize the current understanding of the role of colorectal CSCs in CRC liver metastasis, and provide some insights on the potential implication of colorectal CSCs to better design therapeutic regimens and prevent CRC metastasis.

Keywords: Cancer stem cells, colorectal cancer, liver metastasis.

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