摘要
抑郁症,最常见的情绪障碍,是全世界1亿2000万多人的疾病负担的主要导致因素。各种病理生理过程成为抑郁症的基础,这种复杂性使得它难以确定临床有用的诊断、预后指标以及治疗方案。当前状态的知识驱动的管理和抑郁症的治疗仍然是不完整的,这强调了有关抑郁症的途径需要进一步了解。探索共同病态的条件,如冠状动脉动脉疾病,对进一步阐明抑郁症的发病机制很有用。本综述系统识别并批判性评估在高危人群中抑郁症的相关标志物,即冠心病患者人群中。相关的生物标志物与下丘脑-垂体的- 肾上腺轴功能紊乱、炎症、内皮功能紊乱、血小板活化和聚集、血清素活性、交感神经系统激活、甲状腺功能、结构和形态学异常、、遗传变异、脂质代谢、一个碳代谢,内源性大麻素信号异常和维生素D缺乏已被该综述概括。标记物展示出了与抑郁症的一致相关性,包括肿瘤坏死因子-α、流量介导扩张、内皮素-1、内皮祖细胞、脑源性神经营养因子、和二十二碳六烯酸。进一步调查这些标记的机制和探索新颖的途径,如氧化应激,将扩展目前的知识状态,并有可能导致新的治疗靶点的识别。
关键词: 急性冠脉综合征,生物标志物,共病率,冠状动脉疾病,抑郁,抑郁症状。
Current Molecular Medicine
Title:Potential Biomarkers for Depression Associated with Coronary Artery Disease: A Critical Review
Volume: 16 Issue: 2
Author(s): A. Adibfar, M. Saleem, K.L. Lanctot and N. Herrmann
Affiliation:
关键词: 急性冠脉综合征,生物标志物,共病率,冠状动脉疾病,抑郁,抑郁症状。
摘要: Depression, the most common mood disorder, is a leading contributor to the global burden of disease affecting more than 120 million individuals worldwide. Various pathophysiological processes underlie depression; this complexity renders it difficult to identify clinically useful diagnostic and prognostic markers, as well as treatment options. The current state of knowledge driving the management and treatment of depression remains incomplete, which underscores the need for further insight into pathways relevant to depression. Exploring co-morbid conditions, such as coronary artery disease, may be useful to further elucidate the etiopathology of depression. The present review therefore systematically identifies and critically evaluates relevant markers of depression as assessed in a high-risk population, namely patients with coronary artery disease. Biomarkers related to hypothalamicpituitary- adrenal axis dysregulation, inflammation, endothelial dysfunction, platelet activation and aggregation, serotonin activity, sympathetic nervous system activation, thyroid function, structural and morphological brain abnormalities, genetic variation, lipid metabolism, one-carbon metabolism, endocannabinoid signalling irregularities, and vitamin D deficiency are reviewed. Markers exhibiting the most consistent associations with depression include tumour necrosis factor-α, flow-mediated dilation, endothelin-1, endothelial progenitor cells, brain-derived neurotrophic factor, and docosahexaenoic acid. Further investigating the mechanisms underlying those markers and exploring novel pathways, such as oxidative stress, will extend the current state of knowledge and potentially lead to the identification of novel therapeutic targets.
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Cite this article as:
A. Adibfar, M. Saleem, K.L. Lanctot and N. Herrmann , Potential Biomarkers for Depression Associated with Coronary Artery Disease: A Critical Review, Current Molecular Medicine 2016; 16 (2) . https://dx.doi.org/10.2174/1566524016666160126144143
DOI https://dx.doi.org/10.2174/1566524016666160126144143 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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