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Recent Advances in Cardiovascular Drug Discovery (Discontinued)


ISSN (Print): 1574-8901
ISSN (Online): 2212-3962

Combination of Vasopressin –Epinephrine as a Novel Candidate in Patients with Cardiac Arrest

Author(s): Nasim Ghafourian, Nader H. Maniae, Morovat Taherikalani, Maryam Mehrazi, Mahnaz Hossieni, Firouzeh Valian, Shahriar Karami, Yazdan Rahmatian and Nader Tavakoli

Volume 10, Issue 1, 2015

Page: [65 - 69] Pages: 5

DOI: 10.2174/157489011001160111163856

Price: $65


Objectives: Out-hospital Cardiac arrest is considered as a global disease, which causes high rate of morbidity and mortality. Although, the return of spontaneous circulation occurs in 10 to 60 percent of cases in OHCA, with variety of treatment, the most patients faced with multiple organ failure and ultimately death. The investigations demonstrated that endogenous vasopressin levels in patients with successful resuscitation is more than died patients. Therefore, it seems the administration of vasopressin during cardiopulmonary resuscitation could be useful. The current study aimed to investigate the administration of vasopressin and epinephrine on neurological surviving of cardiac-respiratory arrest via evaluation of S100b serum factor.

Methods: For this reasons, after collecting of sera from two vasopressin-epinephrine and epinephrine receiving patients, sera were subjected for ELISA to evaluate S100b.

Results: The findings demonstrated that the great reductions of S100b in sera of patients that receiving vasopressinepinephrine in comparison with those patients that only got the epinephrine. Although no significant difference was observed between two groups, but survival rates after hospital discharge in group that receiving vasopressin-epinephrine was significantly higher than those patients that only got only epinephrine.

Conclusion: Today, no advantages of vasopressin over epinephrine have been observed in clinical trials and more studies needed to improve the OHAC patient's surveillance. But, The combination vasopressin-epinephrine in the current study demonstrated that efficacy of this combination should be noted.

Keywords: Vasopressin-Epinephrine-S100B, cardiac arrest, cardiopulmonary resuscitation, epinephrine.

Graphical Abstract

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