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Micro and Nanosystems


ISSN (Print): 1876-4029
ISSN (Online): 1876-4037

Blood Flow Visualization and Measurements in Microfluidic Devices Fabricated by a Micromilling Technique

Author(s): Jaron Singhal, Diana Pinho, Raquel Lopes, Patricia C. Sousa, Valdemar Garcia, Helmut Schütte, Rui Lima and Stefan Gassmann

Volume 7, Issue 3, 2015

Page: [148 - 153] Pages: 6

DOI: 10.2174/1876402908666160106000332

Price: $65


The most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 m and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work, we show the ability of a micromilling machine to manufacture microchannels down to 30 µm and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma. Flow visualization and measurements were performed by using a high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process are also presented.

Keywords: Biomedical applications, blood cells, cell-free layer, cells separation, micromilling, microfluidic devices.

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