Cytotoxic Nitrobenzoyloxy-substituted Sesquiterpenes from Spongederived Endozoic Fungus Aspergillus insulicola MD10-2

Title:Cytotoxic Nitrobenzoyloxy-substituted Sesquiterpenes from Spongederived Endozoic Fungus Aspergillus insulicola MD10-2

Volume: 17 Issue: 3

Author(s): Hong-Ying Zhao, Ramasamy Anbuchezhian, Wei Sun, Chang-Lun Shao, Feng-Li Zhang, Ying Yin, Zhi-Sheng Yu, Zhi-Yong Li and Chang-Yun Wang

Affiliation:

Keywords: Marine fungus, Aspergillus insulicola, sponge, sesquiterpene, lung cancer, cytotoxic activity.

Abstract: The emergence of drug resistance and spread of new infectious diseases necessitated the development of novel antibiotics. Marine sponge-associated fungi represent a reservoir of novel molecules with diverse biological potentials. In this study, we isolated five nitrobenzoyloxy-substituted sesquiterpenes 1-5 from the culture mycelia of an endozoic fungus Aspergillus insulicola MD10-2, obtained from the South China Sea sponge Cinachyrella australiensis. Compound 2 showed cytotoxicity against human lung cancer cell line H-460 with an IC₅₀ value of 6.9 µM. Cytotoxicity of the acetylated derivatives (2a and 2b) of compound 2 decreased markedly, suggesting that the hydroxyl group contributed to the cytotoxic activity. Compound 5 was inactive against H-460, which implied the double bond at C-7 had an effect on cytotoxic activity as well.

Cite this article as:

Zhao Hong-Ying, Anbuchezhian Ramasamy, Sun Wei, Shao Chang-Lun, Zhang Feng-Li, Yin Ying, Yu Zhi-Sheng, Li Zhi-Yong and Wang Chang-Yun, Cytotoxic Nitrobenzoyloxy-substituted Sesquiterpenes from Spongederived Endozoic Fungus Aspergillus insulicola MD10-2, Current Pharmaceutical Biotechnology 2016; 17 (3) . https://dx.doi.org/10.2174/1389201017666151223123424