Abstract
Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
Keywords: Calcium phosphate, hydroxyapatite, bioceramics, gene delivery, transfection, biocompatibility.
Current Pharmaceutical Design
Title:Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities
Volume: 22 Issue: 11
Author(s): Babak Mostaghaci, Brigitta Loretz and Claus-Michael Lehr
Affiliation:
Keywords: Calcium phosphate, hydroxyapatite, bioceramics, gene delivery, transfection, biocompatibility.
Abstract: Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
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Cite this article as:
Mostaghaci Babak, Loretz Brigitta and Lehr Claus-Michael, Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities, Current Pharmaceutical Design 2016; 22 (11) . https://dx.doi.org/10.2174/1381612822666151210123859
DOI https://dx.doi.org/10.2174/1381612822666151210123859 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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