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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Biosystems Engineering of Prokaryotes with Tumor-Killing Capacities

Author(s): Ebuzer Kalyoncu, Tolga T. Olmez, Alper D. Ozkan and Omer F. Sarioglu

Volume 22, Issue 11, 2016

Page: [1521 - 1528] Pages: 8

DOI: 10.2174/1381612822666151210123752

Price: $65

Abstract

Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic infection. Genetic engineering can be used to minimize the risks associated with tumor-targeting pathogens, as well as to increase their efficiency in killing tumor cells. Advances in genetic circuit design have led to the development of bacterial strains with enhanced tumor-targeting capacities and the ability to secrete therapeutics, cytotoxic proteins and prodrug-cleaving enzymes, which allows their safe and effective use for cancer treatment. The present review details the recent advances in the design and application of these modified bacterial strains.

Keywords: Synthetic biology, cancer therapy, live vaccines, prodrug cleavage, Salmonella, Clostridium, Bifidobacterium.


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