摘要
蛋白质丝氨酸/苏氨酸磷酸酶-1和-2A是主要的细胞磷酸酶,从原核生物到真核生物扮演生物的基础性作用,他们促成了90%脱磷酸化的真核生物蛋白。在眼部,包括磷酸酶高效表达和调节正常眼睛发育显示重要的功能。此外,它们通过应力诱导的细胞凋亡的调节中牵涉的发病机制。在这里,我们回顾这些方面的最新进展。
关键词: 丝氨酸/苏氨酸磷酸-1和2A号,眼部发育,晶状体变异,发展性细胞凋亡
Current Molecular Medicine
Title:Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A
Volume: 15 Issue: 10
Author(s): L. Wang, Y. Yang, X. -D. Gong, Z. -X. Huang, Q. Nie, Z. -F. Wang, W. -K. Ji, X. -H. Hu, W. -F. Hu and , L. -L. Gong, L. Zhang, S. Huang, R. -L. Qi, T. -H. Yang, Z. -G. Chen, W. -B. Liu, Y. -Z. Liu and D. W. -C. Li
Affiliation:
关键词: 丝氨酸/苏氨酸磷酸-1和2A号,眼部发育,晶状体变异,发展性细胞凋亡
摘要: The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
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L. Wang, Y. Yang, X. -D. Gong, Z. -X. Huang, Q. Nie, Z. -F. Wang, W. -K. Ji, X. -H. Hu, W. -F. Hu and , L. -L. Gong, L. Zhang, S. Huang, R. -L. Qi, T. -H. Yang, Z. -G. Chen, W. -B. Liu, Y. -Z. Liu and D. W. -C. Li , Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/156652401510151125125127
DOI https://dx.doi.org/10.2174/156652401510151125125127 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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