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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Regulation of Eye Development by Protein Serine/Threonine Phosphatases-1 and -2A

Author(s): L. -L. Gong, D. W. -C. Li, Y. -Z. Liu, W. -B. Liu, Z. -G. Chen, T. -H. Yang, R. -L. Qi, S. Huang, L. Zhang, L. Wang, W. -F. Hu, X. -H. Hu, W. -K. Ji, Z. -F. Wang, Q. Nie, Z. -X. Huang, X. -D. Gong and Y. Yang

Volume 15, Issue 10, 2015

Page: [944 - 951] Pages: 8

DOI: 10.2174/156652401510151125125127

Price: $65


The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Keywords: Serine/threonine phosphatases-1 and -2A, eye development, lens differentiation, developmental apoptosis.

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