阿尔茨海默病中的小胶质细胞：好的，坏的和丑陋的

Title:Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly

Volume: 13 Issue: 4

Author(s): Dario Tejera, Michael T. Heneka

Affiliation:

关键词: 阿尔茨海默病；淀粉样蛋白β；细胞因子；神经炎症；神经退行性病变；小胶质细胞。

摘要: Traditionally the brain has been viewed as being an immune-privileged organ. However, endogenous stimuli such as the presence of misfolded or aggregated proteins, as well as systemic inflammatory events may lead to the activation of microglial cells, the brain´s innate immune system, and, subsequently, to neuroinflammation. Alzheimer's disease, the leading cause of dementia, is characterized by amyloid beta deposition and tau hyperphosphorylation. Neuroinflammation in Alzheimer's disease has been identified as major contributor to disease pathogenesis. Once activated, microglia release several pro and anti-inflammatory mediators of which several affect the function and structure of the brain. Modulation of this microglial activation in Alzheimer's disease might open new therapeutic avenues.

Cite this article as:

Dario Tejera, Michael T. Heneka , Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly, Current Alzheimer Research 2016; 13 (4) . https://dx.doi.org/10.2174/1567205013666151116125012