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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly

Author(s): Dario Tejera and Michael T. Heneka

Volume 13 , Issue 4 , 2016

Page: [370 - 380] Pages: 11

DOI: 10.2174/1567205013666151116125012

Price: $65

Abstract

Traditionally the brain has been viewed as being an immune-privileged organ. However, endogenous stimuli such as the presence of misfolded or aggregated proteins, as well as systemic inflammatory events may lead to the activation of microglial cells, the brain´s innate immune system, and, subsequently, to neuroinflammation. Alzheimer's disease, the leading cause of dementia, is characterized by amyloid beta deposition and tau hyperphosphorylation. Neuroinflammation in Alzheimer's disease has been identified as major contributor to disease pathogenesis. Once activated, microglia release several pro and anti-inflammatory mediators of which several affect the function and structure of the brain. Modulation of this microglial activation in Alzheimer's disease might open new therapeutic avenues.

Keywords: Alzheimer's, amyloid-β, cytokines, neuroinflammation, neurodegeneration, microglia.


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