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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Neural Mechanisms of Exercise: Effects on Gut Miccrobiota and Depression

Author(s): Ti-Fei Yuan, Nuno Barbosa Ferreira Rocha, Flávia Paes, Oscar Arias-Carrión, Sergio Machado and Alberto Souza de Sá Filho

Volume 14, Issue 10, 2015

Page: [1312 - 1314] Pages: 3

DOI: 10.2174/1871527315666151111124729

Price: $65


Microbiota is a set of microorganisms resident in gut ecosystem that reacts to psychological stressful stimuli, and is involved in depressed or anxious status in both animals and human being. Interestingly, a series of studies have shown the effects of physical exercise on gut microbiota dynamics, suggesting that gut microbiota regulation might act as one mediator for the effects of exercise on the brain. Recent studies found that gut microbiota dynamics are also regulated by metabolism changes, such as through physical exercise or diet change. Interestingly, physical exercise modulates different population of gut bacteria in compared to food restriction or rich diet, and alleviates gut syndromes to toxin intake. Gut microbiota could as well contribute to the beneficial effects of exercise on cognition and emotion, either directly through serotonin signaling or indirectly by modulating metabolism and exercise performance.

Keywords: Depression, exercise, gut microbiota.

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