Abstract
Cognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant. Lack of methodological consistency, mainly related to exercise, makes it difficult accuracy and extrapolation of the results. Nevertheless, mechanisms related to BD physiopathology, such as hormonal and neurotransmitters alterations and mainly related to brain-derived neurotrophic factors (BDNF) can be explored. BDNF, specially, have a large influence on brain ability and its gene expression is highly responsive to aerobic exercise. Moreover, aerobic exercise trough BDNF may induce chronic stress suppression, commonly observed in patients with BD, and reduce deleterious effects caused by allostatic loads. Therefore, it is prudent to propose that aerobic exercise plays an important role in BD physiopathological mechanisms and it is a new way for the treatment for this and others psychiatric disorders.
Keywords: Bipolar disorder, brain-derived neurotrophic factor, depression, exercise, mania, neuroplasticity.
CNS & Neurological Disorders - Drug Targets
Title:Potential Therapeutic Effects of Physical Exercise for Bipolar Disorder
Volume: 14 Issue: 10
Author(s): Joao Manochio, Sergio Machado, Antonio Egidio Nardi, Ti-Fei Yuan, Elie Cheniaux, Oscar Arias-Carrión, Gioia Mura, Mirko Wegner, Henning Budde, Alberto Souza de Sa Filho, Ridson Rimes, Eduardo Lattari, Ana Cristina Oliveira, Flavia Paes, Nuno Barbosa Ferreira Rocha, Murilo Khede Lamego and Antonio Marcos de Souza Moura
Affiliation:
Keywords: Bipolar disorder, brain-derived neurotrophic factor, depression, exercise, mania, neuroplasticity.
Abstract: Cognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant. Lack of methodological consistency, mainly related to exercise, makes it difficult accuracy and extrapolation of the results. Nevertheless, mechanisms related to BD physiopathology, such as hormonal and neurotransmitters alterations and mainly related to brain-derived neurotrophic factors (BDNF) can be explored. BDNF, specially, have a large influence on brain ability and its gene expression is highly responsive to aerobic exercise. Moreover, aerobic exercise trough BDNF may induce chronic stress suppression, commonly observed in patients with BD, and reduce deleterious effects caused by allostatic loads. Therefore, it is prudent to propose that aerobic exercise plays an important role in BD physiopathological mechanisms and it is a new way for the treatment for this and others psychiatric disorders.
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Cite this article as:
Manochio Joao, Machado Sergio, Nardi Egidio Antonio, Yuan Ti-Fei, Cheniaux Elie, Arias-Carrión Oscar, Mura Gioia, Wegner Mirko, Budde Henning, de Sa Filho Souza Alberto, Rimes Ridson, Lattari Eduardo, Oliveira Cristina Ana, Paes Flavia, Ferreira Rocha Barbosa Nuno, Lamego Khede Murilo and de Souza Moura Marcos Antonio, Potential Therapeutic Effects of Physical Exercise for Bipolar Disorder, CNS & Neurological Disorders - Drug Targets 2015; 14 (10) . https://dx.doi.org/10.2174/1871527315666151111122219
DOI https://dx.doi.org/10.2174/1871527315666151111122219 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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