Abstract
Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.
Keywords: NMR spectroscopy, crystallography, oligosaccharides, carbohydrates
Current Medicinal Chemistry
Title: Structural Aspects of Carbohydrates and the Relation with their Biological Properties
Volume: 11 Issue: 19
Author(s): Milos Hricovini
Affiliation:
Keywords: NMR spectroscopy, crystallography, oligosaccharides, carbohydrates
Abstract: Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.
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Cite this article as:
Hricovini Milos, Structural Aspects of Carbohydrates and the Relation with their Biological Properties, Current Medicinal Chemistry 2004; 11 (19) . https://dx.doi.org/10.2174/0929867043364414
DOI https://dx.doi.org/10.2174/0929867043364414 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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