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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Structural Aspects of Carbohydrates and the Relation with their Biological Properties

Author(s): Milos Hricovini

Volume 11 , Issue 19 , 2004

Page: [2565 - 2583] Pages: 19

DOI: 10.2174/0929867043364414

Price: $65


Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.

Keywords: NMR spectroscopy, crystallography, oligosaccharides, carbohydrates

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