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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs

Author(s): Laszlo Orfi, Frigyes Waczek, Janos Pato, Istvan Varga, Balint Hegymegi-Barakonyi, Richard A. Houghten and Gyorgy Ker

Volume 11 , Issue 19 , 2004

Page: [2549 - 2553] Pages: 5

DOI: 10.2174/0929867043364423

Price: $65

Abstract

Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases [1]. One of the most important compound

Keywords: pyrimidines, quinazolin-4-ones, formamidine-acetate, imidoyl-chlorides, purine analogs, protein kinase inhibitors, antiproliferative agents, phosphodiesterase v inhibitors


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