Abstract
Bioorthogonal reactions have been widely used on live-cell labeling, animal tissue imaging, drug delivery, and biomaterials in the recent ten years. Tetrazine bioorthogonal chemistry is not only orthogonal with biological system, other click chemistry and traditional polymer chemistry, but also has superb kinetics, generates biocompatibility products, and proceeds under mild reaction condition. All these features enable tetrazine bioorthogonal chemistry to be widely applied to polymer and biomaterial science. Recently there are many exciting accomplishments. This chemistry can act as an ideal method for polymer and nanoparticle modification, a desired vehicle for nanoparticles in vivo delivery, new polymerization strategy, and novel hydrogel formation platform. In this review, we introduce recent advancements in biomaterials based on tetrazine bioorthogonal chemistry.
Keywords: Bioorthogonal chemistry, tetrazine, polymer, biomaterials, nanoparticles.
Current Organic Chemistry
Title:Tetrazine Bioorthogonal Reaction: A Novel Scheme for Polymer and Biomaterials
Volume: 20 Issue: 17
Author(s): Hongyan Zhu, Haoxing Wu, Min Wu and Qiyong Gong
Affiliation:
Keywords: Bioorthogonal chemistry, tetrazine, polymer, biomaterials, nanoparticles.
Abstract: Bioorthogonal reactions have been widely used on live-cell labeling, animal tissue imaging, drug delivery, and biomaterials in the recent ten years. Tetrazine bioorthogonal chemistry is not only orthogonal with biological system, other click chemistry and traditional polymer chemistry, but also has superb kinetics, generates biocompatibility products, and proceeds under mild reaction condition. All these features enable tetrazine bioorthogonal chemistry to be widely applied to polymer and biomaterial science. Recently there are many exciting accomplishments. This chemistry can act as an ideal method for polymer and nanoparticle modification, a desired vehicle for nanoparticles in vivo delivery, new polymerization strategy, and novel hydrogel formation platform. In this review, we introduce recent advancements in biomaterials based on tetrazine bioorthogonal chemistry.
Export Options
About this article
Cite this article as:
Zhu Hongyan, Wu Haoxing, Wu Min and Gong Qiyong, Tetrazine Bioorthogonal Reaction: A Novel Scheme for Polymer and Biomaterials, Current Organic Chemistry 2016; 20 (17) . https://dx.doi.org/10.2174/1385272820666151102212821
DOI https://dx.doi.org/10.2174/1385272820666151102212821 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Interaction between Basic 7S Globulin and Leginsulin in Soybean [Glycine max]: A Structural Insight
Letters in Drug Design & Discovery Quantitative Structure-Wavelength Relationship Modeling of Porphin -Derivative Photosensitizers
Combinatorial Chemistry & High Throughput Screening Enhancement of the Antiproliferative Activity of Gemcitabine by Modulation of c-Met Pathway in Pancreatic Cancer
Current Pharmaceutical Design Targeting the Voltage-Dependent K+ Channels Kv1.3 and Kv1.5 as Tumor Biomarkers for Cancer Detection and Prevention
Current Medicinal Chemistry Genomic and Proteomic Techniques and their Application in Selenium Research
Current Pharmacogenomics Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics
Current Medicinal Chemistry Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention
Current Topics in Medicinal Chemistry Tumor-Targeting Peptides and Small Molecules as Anti-Cancer Agents to Overcome Drug Resistance
Current Medicinal Chemistry Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy
Current Drug Metabolism GCPII Imaging and Cancer
Current Medicinal Chemistry Quinoline as a Privileged Scaffold in Cancer Drug Discovery
Current Medicinal Chemistry Neuroprotective Effects of Quercetin: From Chemistry to Medicine
CNS & Neurological Disorders - Drug Targets Blind Snipers: Relevant Off Target Effects of Non-chemotherapeutic Agents in Oncology: Review of the Literature
Reviews on Recent Clinical Trials Biodegradable Polymer Based Particulate Carrier(s) for the Delivery of Proteins and Peptides
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Subject Index to Volume 5
Current Genomics Integrin αvβ3 Antagonists for Anti-Angiogenic Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery ADAM8 in Allergy
Inflammation & Allergy - Drug Targets (Discontinued) Phosphorothioate-Stimulated Uptake of siRNA by Mammalian Cells: A Novel Route for Delivery
Current Topics in Medicinal Chemistry Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics
Current Drug Targets Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its Biochemical, Cytotoxic Activity and Various Analyses Through Computational and Bio-Programming Methods
Current Pharmaceutical Design