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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Advances in Peptide-based DNA/RNA-Intercalators

Author(s): Josipa Matić, Lidija-Marija Tumir, Marijana Radić Stojković and Ivo Piantanida

Volume 17 , Issue 2 , 2016

Page: [127 - 134] Pages: 8

DOI: 10.2174/138920371702160209124439

Price: $65


Interactions between DNA/RNA and huge variety of peptides are quite common in nature, controlling vast number of processes. Also, there are several naturally occurring small molecules which contain peptide and DNA intercalator in structure, whereby their biological activity is based on synergistic interactions of both components; for instance bis-intercalator echinomycin. Versatility of synthetic approaches to short peptides allowed their usage as simple recognition units within the DNA or RNA grooves or as backbone carriers for variety of bioactive substituents attached to amino acid side chains, one of very popular examples being PNAs. Such peptide-backbones were also used for synthesis of novel intercalators and poly-intercalators, many of them showing intriguing novel DNA/RNA interacting properties.

Keywords: DNA, RNA, peptide, intercalator, fluorescence, DNA-cleavage.

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