Abstract
Metabolites of the thermophilic fungi Myriococcum albomyces and Mycelia sterilia such as myriocin (1), the mycestericins (2-8) and the sphingofungins (13-18) structurally resemble the sphingosines, important components of cell membranes. All the compounds revealed in vitro remarkable immunosuppressive activity and their pharmaceutical potential has led to the development of promising novel immunosuppressants. This review article describes the abundance, biology and chemistry of these metabolites.
Keywords: homologues, sphingosines, myriocin, immunosuppressant, isolation, fermentation, diseases, total syntheses
Current Organic Chemistry
Title: Biology and Chemistry of Sphingosine-Related Metabolites
Volume: 8 Issue: 17
Author(s): Martin Brunner and Ari M. P. Koskinen
Affiliation:
Keywords: homologues, sphingosines, myriocin, immunosuppressant, isolation, fermentation, diseases, total syntheses
Abstract: Metabolites of the thermophilic fungi Myriococcum albomyces and Mycelia sterilia such as myriocin (1), the mycestericins (2-8) and the sphingofungins (13-18) structurally resemble the sphingosines, important components of cell membranes. All the compounds revealed in vitro remarkable immunosuppressive activity and their pharmaceutical potential has led to the development of promising novel immunosuppressants. This review article describes the abundance, biology and chemistry of these metabolites.
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Cite this article as:
Brunner Martin and Koskinen M. P. Ari, Biology and Chemistry of Sphingosine-Related Metabolites, Current Organic Chemistry 2004; 8 (17) . https://dx.doi.org/10.2174/1385272043369638
DOI https://dx.doi.org/10.2174/1385272043369638 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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