Nutrition in Allogeneic Stem Cell Transplantion - Clinical Guidelines and Immunobiological Aspects

Title:Nutrition in Allogeneic Stem Cell Transplantion - Clinical Guidelines and Immunobiological Aspects

Volume: 17 Issue: 1

Author(s): Tor H.A. Tvedt, Håkon Reikvam and Øystein Bruserud

Affiliation:

Keywords: Allogeneic, Stem cell transplantation, graft versus host disease, T cells, dendritic cells, metabolism, nutrition.

Abstract: Even though malnutrition is associated with an adverse prognosis after allogeneic stem cell transplantation, few studies have addressed the question what is the optimal nutritional support for these patients. There is a general agreement that the body weight, body mass index and nutritional intake can be used to guide the post-transplant nutritional support; enteral nutrition may then be tried but most patients will require parenteral nutrition. There is no scientific basis for further standardization of post-transplant nutritional support. The nutritional status with regard to amino acid as well as fatty acid metabolism and vitamin levels are important for immunoregulation. Several amino acids and their metabolites function as signaling molecules through their binding to specific receptors, and they are thereby become important both in dendritic cell differentiation and T cell activation and the metabolic switch that often occurs during the activation of immunocompetent cells. We review previous studies of nutritional support in allotransplant recipients and discuss possible molecular mechanisms involved in metabolic immunoregulation and the development of post-transplant immunemediated complications.

Cite this article as:

Tvedt H.A. Tor, Reikvam Håkon and Bruserud Øystein, Nutrition in Allogeneic Stem Cell Transplantion - Clinical Guidelines and Immunobiological Aspects, Current Pharmaceutical Biotechnology 2016; 17(1) . https://dx.doi.org/10.2174/138920101701151027163600