Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that gradually induces cognitive deficit. Working memory deficits have been previously reported in AD and Amyloid-β peptide (Aβ) is regarded as a causative factor for the impairments. Accumulating evidence has identified that neuronal ensemble activity as well as functional connectivity among neurons encode and process information in normal brain. How Aβ contributes to the abnormal neuronal ensemble activity and corresponding functional connectivity which, in turn, leads to the cognitive deficits? To address the issue, we simultaneously recorded neuronal activity from medial prefrontal cortex of rats (control and Aβ injected group) when the rats performed a Y-maze working memory task, to investigate the properties of neuronal ensemble activity and functional connectivity. In the control group, a group of neurons were collectively activated and the connectivity among the neurons strengthened during the working memory task. However, in the Aβ group, the neuronal activity and connectivity never experience significant change. Our results indicate that the dysfunction of neuronal activity and connectivity may provide insight for the Aβ-induced working memory deficits.
Keywords: Alzheimer's disease (AD), amyloid-β peptide (Aβ), functional connectivity, neuronal ensemble activity, rat, working memory.
Current Alzheimer Research
Title:Aberrant Neuronal Activity and Dysfunctional Connectivity in Aβ1–42- mediated Memory Deficits in Rats
Volume: 12 Issue: 10
Author(s): Jing Wei, Hu Yi, Dan Zhang, Wenwen Bai and Xin Tian
Affiliation:
Keywords: Alzheimer's disease (AD), amyloid-β peptide (Aβ), functional connectivity, neuronal ensemble activity, rat, working memory.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that gradually induces cognitive deficit. Working memory deficits have been previously reported in AD and Amyloid-β peptide (Aβ) is regarded as a causative factor for the impairments. Accumulating evidence has identified that neuronal ensemble activity as well as functional connectivity among neurons encode and process information in normal brain. How Aβ contributes to the abnormal neuronal ensemble activity and corresponding functional connectivity which, in turn, leads to the cognitive deficits? To address the issue, we simultaneously recorded neuronal activity from medial prefrontal cortex of rats (control and Aβ injected group) when the rats performed a Y-maze working memory task, to investigate the properties of neuronal ensemble activity and functional connectivity. In the control group, a group of neurons were collectively activated and the connectivity among the neurons strengthened during the working memory task. However, in the Aβ group, the neuronal activity and connectivity never experience significant change. Our results indicate that the dysfunction of neuronal activity and connectivity may provide insight for the Aβ-induced working memory deficits.
Export Options
About this article
Cite this article as:
Wei Jing, Yi Hu, Zhang Dan, Bai Wenwen and Tian Xin, Aberrant Neuronal Activity and Dysfunctional Connectivity in Aβ1–42- mediated Memory Deficits in Rats, Current Alzheimer Research 2015; 12 (10) . https://dx.doi.org/10.2174/1567205012666151027141324
DOI https://dx.doi.org/10.2174/1567205012666151027141324 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot Topic: Bringing Drugs Into the Injured Brain and Keeping Them There (Executive Guest Editors: Dirk M. Hermann and Pauline Patak)]
Current Pharmaceutical Design Flavonoids as Promising Lead Compounds in Type 2 Diabetes Mellitus: Molecules of Interest and Structure-Activity Relationship
Current Medicinal Chemistry Chemistry and Pharmacology of Bioactive Molecule -Coenzyme Q10: A Brief Note
Current Bioactive Compounds The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism
Current Alzheimer Research Water and Ion Channels: Crucial in the Initiation and Progression of Apoptosis in Central Nervous System?
Current Neuropharmacology Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics
Current Genomics Procedure for Identification and Characterization of Drugs Efficient Against Mammalian Prion: From a Yeast-Based Antiprion Drug Screening Assay to In Vivo Mouse Models
Infectious Disorders - Drug Targets Heme Oxygenase-2 Protects Against Glutathione Depletion-induced Neuronal Apoptosis Mediated by Bilirubin and Cyclic GMP
Current Neurovascular Research Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment
Current Alzheimer Research Pathophysiology of Neurodegeneration in Familial Amyotrophic Lateral Sclerosis
Current Molecular Medicine Neurogenesis in Alzheimers Disease: A Realistic Alternative to Neuronal Degeneration?
Current Signal Transduction Therapy Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases
Current Neurovascular Research Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity
Current Alzheimer Research Microglial Activation in Alzheimers Disease
Current Alzheimer Research Tau as a Therapeutic Target for Alzheimers Disease
Current Alzheimer Research The Role of Inflammation in Neurological Disorders
Current Pharmaceutical Design Histone Deacetylase (HDAC) Inhibitors as Potential Drugs to Target Memory and Adult Hippocampal Neurogenesis
Current Psychopharmacology [General Articles] Altered Protein Acetylation in Polyglutamine Diseases
Current Medicinal Chemistry Meet Our Editorial Board Member
Recent Patents on Biotechnology (Commentary [Research Highlights] A Toll Road to Alzheimer Disease?)
CNS & Neurological Disorders - Drug Targets