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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

Umbilical Cord is a Rich Source of Mesenchymal Stromal Cells for Cell Therapy

Author(s): Tokiko Nagamura-Inoue and Takeo Mukai

Volume 11, Issue 8, 2016

Page: [634 - 642] Pages: 9

DOI: 10.2174/1574888X10666151026115017

Price: $65

Abstract

Recently, umbilical cord (UC) and UC-derived mesenchymal stromal cells (UC-MSCs) have attracted much attention for many reasons, including (1) abundant sources and ease of collection, storage, and transport; (2) little ethical controversy; (3) multipotency to differentiate into various cell types; and (4) low immunogenicity with significant immunosuppressive ability. In this review, we provide a brief introduction to UC and UC-MSCs in terms of characteristics, isolation, and cryopreservation, as well as emphasizing their potential clinical application in regenerative medicine and immunotherapy.

Keywords: Cryopreservation, explant, immunosuppression, mesenchymal stromal cells, stem cell therapy, umbilical cord.


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