Abstract
An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.
Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.
Letters in Drug Design & Discovery
Title:Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive
Volume: 13 Issue: 6
Author(s): Alajos Grun, Dávid Illés Nagy, Sándor Garadnay, István Greiner and Gyorgy Keglevich
Affiliation:
Keywords: Pamidronic acid, best synthesis, additive, ionic liquids, intermediate.
Abstract: An efficient method was developed for the synthesis of pamidronic acid involving the reaction of β-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 °C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.
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Cite this article as:
Grun Alajos, Illés Nagy Dávid, Garadnay Sándor, Greiner István and Keglevich Gyorgy, Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180812666151022221805
DOI https://dx.doi.org/10.2174/1570180812666151022221805 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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