Abstract
Background: The human and environmental exposure to titanium dioxide is currently large-scale. Taking into account that for TiO2 the peroral route of exposure seems to be a very important route of exposure for humans, knowledge of its biodistribution and toxicity after the peroral uptake, is highly relevant for the human health risk assessment of TiO2 NPs. The present study compares the biodistribution of titanium dioxide nanoparticles of different sizes (5-10 nm and 20-25 nm) after peroral administration to rats.
Methods: For comparison of the biodistributions of titanium dioxide nanoparticles, male rats were intragastrically administered with two specimens of TiO2 nanoparticles for a 28-day period at a daily dose of 250 mg/kg of body weight. Titanium dioxide was detected in rats` organs and tissues by atomic absorption spectroscopy.
Results: The absorption from the gastrointestinal tract (GIT) and translocation into secondary organs of titanium dioxide occurred in a size-dependent manner. After administration of the smaller nanoparticles, titanium was found in the brain, lungs, heart, liver, kidneys, spleen, small intestine, testicles, and blood (0.004–0.227 µg/g of organ), whereas after administration of the larger nanoparticles, titanium was accumulated only in the liver, kidneys, spleen, and small intestine (0.01– 0.29 µg/g of organ). The amounts of the detected titanium are much smaller than the administered doses. After repeateddose exposures, no animal deaths or toxicity indications were observed.
Conclusions: The penetration of titanium dioxide nanoparticles from the GIT of rats into the bloodstream and their translocation into secondary organs are size-dependent and has no evident toxic effect.
Keywords: Biodistribution, intragastric administration, sub-acute, titanium dioxide nanoparticles.
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Books
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts
Applications of Nanomaterials in Medical Procedures and Treatments
Synthesis of Nanomaterials
Nanobiotechnology: Principles and Applications
Bio-Inspired Nanotechnology
26
1
1
1