Abstract
An increasing body of evidence from animal models, human specimens and cell lines points to reactive oxygen species as likely involved in the pathways, which convey both extracellular and intracellular signals to the nucleus, under a variety of pathophysiological conditions. Indeed, reactive oxygen species (ROS), in a concentration compatible with that detectable in human pathophysiology, appear able to modulate a number of kinases and phosphatases, redox sensitive transcription factors and genes. This type of cell signalling consistently implies the additional involvement of other bioactive molecules that stem from ROS reaction with cell membrane lipids. The present review aims to comprehensively report on the most recent knowledge about the potential role of ROS and oxidised lipids in signal transduction processes in the major events of cell and tissue pathophysiology. Among the lipid oxidation products of ROS-dependent reactivity, which appear as candidates for a signalling role, there are molecules generated by oxidation of cholesterol, polyunsaturated fatty acids and phospholipids, as well as lysophosphatidic acid and lysophospholipids, platelet activating factor-like lipids, isoprostanes, sphingolipids and ceramide.
Keywords: ros, cell signalling, oxysterols, 4-hydroxynonenal, lysophosphatidic acid, oxidised phospholipids, ceramide, lysophospholipids
Current Medicinal Chemistry
Title: Oxidative Stress and Cell Signalling
Volume: 11 Issue: 9
Author(s): G. Poli, G. Leonarduzzi, F. Biasi and E. Chiarpotto
Affiliation:
Keywords: ros, cell signalling, oxysterols, 4-hydroxynonenal, lysophosphatidic acid, oxidised phospholipids, ceramide, lysophospholipids
Abstract: An increasing body of evidence from animal models, human specimens and cell lines points to reactive oxygen species as likely involved in the pathways, which convey both extracellular and intracellular signals to the nucleus, under a variety of pathophysiological conditions. Indeed, reactive oxygen species (ROS), in a concentration compatible with that detectable in human pathophysiology, appear able to modulate a number of kinases and phosphatases, redox sensitive transcription factors and genes. This type of cell signalling consistently implies the additional involvement of other bioactive molecules that stem from ROS reaction with cell membrane lipids. The present review aims to comprehensively report on the most recent knowledge about the potential role of ROS and oxidised lipids in signal transduction processes in the major events of cell and tissue pathophysiology. Among the lipid oxidation products of ROS-dependent reactivity, which appear as candidates for a signalling role, there are molecules generated by oxidation of cholesterol, polyunsaturated fatty acids and phospholipids, as well as lysophosphatidic acid and lysophospholipids, platelet activating factor-like lipids, isoprostanes, sphingolipids and ceramide.
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Cite this article as:
Poli G., Leonarduzzi G., Biasi F. and Chiarpotto E., Oxidative Stress and Cell Signalling, Current Medicinal Chemistry 2004; 11 (9) . https://dx.doi.org/10.2174/0929867043365323
DOI https://dx.doi.org/10.2174/0929867043365323 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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