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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Biological and Chemical Diversity of Coral-Derived Microorganisms

Author(s): Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang and Chang-Lun Shao

Volume 22 , Issue 32 , 2015

Page: [3707 - 3762] Pages: 56

DOI: 10.2174/0929867322666151006093755

Price: $65


Coral-derived microorganisms have been a major focus of many research efforts on marine ecology in recent decades. Importantly, research on bioactive compounds from these diverse microorganisms, which include fungi and bacteria, has experienced an explosive growth during the past five years. This has unveiled the ecological roles of these microorganisms, which prevent antifouling, inhibit pathogenic bacteria, and deter predators in ocean ecosystems. Moreover, the structural diversity and pharmacological activity of the compounds produced by these microorganisms have also been studied extensively, leading not only to an understanding their roles within ecosystems, but also the potential value of their use in human health. In this review, 258 marine natural products, including polyketides, terpenoids, meroterpenoids, alkaloids, peptides, shikimates and lipids, all discovered in the past 24 years, are presented. 146 references are cited.

Keywords: Alkaloids, antifouling, antimicroorganisms, antitumor, biodiversity, coral-derived microorganisms, polyketides.

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