Heterogeneous Diastereoselective Catalysis - A Powerful Strategy Toward C(15) Stereoselectivity from PGF_2α Analogues Structure

Title:Heterogeneous Diastereoselective Catalysis - A Powerful Strategy Toward C(15) Stereoselectivity from PGF_2α Analogues Structure

Volume: 21 Issue: 38

Author(s): Simona M. Coman and Vasile I. Parvulescu

Affiliation:

Keywords: Prostaglandins, cloprostenol, diastereoselectivity, chiral modifier, hydrogenation, heterogeneous catalysis.

Abstract: major trend in fine chemicals and pharmaceuticals is the synthesis of molecules with increased complexity. This trend translates the aim of organic syntheses to conditions in which high degrees of chemo-, regioand stereoselectivity can be provided. In this context, the chemoselective hydrogenation of one functional group in the presence of other reactive groups is a frequently encountered problem in fine chemicals manufacture. This study provides a critical analysis including elegant examples of reactions in which high chemo- and diastereoselectivities were achieved in the hydrogenation of a C=O group in the presence of C=C double bond. A particular emphasis is addressed to the stereoselective C(15) synthesis from Cloprostenol - a PGF_2α structural analogue.

Cite this article as:

Coman M. Simona and Parvulescu I. Vasile, Heterogeneous Diastereoselective Catalysis - A Powerful Strategy Toward C(15) Stereoselectivity from PGF_2α Analogues Structure, Current Pharmaceutical Design 2015; 21(38) . https://dx.doi.org/10.2174/1381612821666151002113246