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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Silver and Other Metals in the Treatment of Gastrointestinal Diseases

Author(s): Krzysztof Siczek, Hubert Zatorski and Jakub Fichna

Volume 22, Issue 32, 2015

Page: [3695 - 3706] Pages: 12

DOI: 10.2174/0929867322666151001121439

Price: $65


Disturbance in the functioning of the gastrointestinal (GI) tract can critically affect the health and even the life of the whole organism. Several factors, both exo- and endogenous may contribute to the dysregulation of homeostasis in the digestive system, including genetic background, ingestion of highly processed food, exposition to environmental pollution or chronic stress, and changes in gut microflora, to name just a few. An important number of these factors rely on metals, which often play a dual, stimulatory and inhibitory role in crucial physiological processes.

In this paper, we focus on the structures incorporating silver, copper and other metals as future drugs against GI diseases. We critically review available literature for their effectiveness and potential application, and discuss clinical relevance of these findings.

Keywords: Colorectal cancer, gastrointestinal tract, inflammatory bowel diseases, microbiota, nanoparticles, silver.

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