Abstract
Microcephaly is a clinical condition defined as a reduction in head circumference and brain volume. The abnormal brain size may result from pathological neural stem cell (NSC) proliferation, survival, differentiation and migration during the development of the cerebral cortex. This process is controlled by many factors, including microRNAs that normally silence target genes at the posttranscriptional level. In this review, we will discuss the roles of microRNAs involved in different stages of the cortical development to shed light on the pathogenesis of microcephaly. Understanding the molecular mechanisms of microRNA-mediated cortical development may help develop a means of microRNA-based diagnosis and treatment for microcephaly in humans.
Keywords: Cerebral cortex, microcephaly, microRNA, neural stem cell, neural progenitor, neurogenesis.
Current Molecular Pharmacology
Title:microRNAs and Molecular Pathogenesis of Microcephaly
Volume: 9
Author(s): Xuqing Liu and Tao Sun
Affiliation:
Keywords: Cerebral cortex, microcephaly, microRNA, neural stem cell, neural progenitor, neurogenesis.
Abstract: Microcephaly is a clinical condition defined as a reduction in head circumference and brain volume. The abnormal brain size may result from pathological neural stem cell (NSC) proliferation, survival, differentiation and migration during the development of the cerebral cortex. This process is controlled by many factors, including microRNAs that normally silence target genes at the posttranscriptional level. In this review, we will discuss the roles of microRNAs involved in different stages of the cortical development to shed light on the pathogenesis of microcephaly. Understanding the molecular mechanisms of microRNA-mediated cortical development may help develop a means of microRNA-based diagnosis and treatment for microcephaly in humans.
Export Options
About this article
Cite this article as:
Liu Xuqing and Sun Tao, microRNAs and Molecular Pathogenesis of Microcephaly, Current Molecular Pharmacology 2016; 9 (4) . https://dx.doi.org/10.2174/1874467208666150928153949
DOI https://dx.doi.org/10.2174/1874467208666150928153949 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
New Onset ADHD Symptoms in Adolescents and College Students: Diagnostic Challenges and Recommendations
Adolescent Psychiatry Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?
Current Molecular Pharmacology Is a "Mitochondrial Psychiatry" in the Future? A Review
Current Psychiatry Reviews Plasma-Rich in Growth Factor and its Clinical Application
Current Stem Cell Research & Therapy Alzheimer’s Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin
Current Alzheimer Research Simultaneous Quantification of Citalopram and its Main Metabolite, Desmethylcitalopram, in Human Saliva by UHPLC
Current Analytical Chemistry Measurement of Palmitoylethanolamide and Other N-Acylethanolamines During Physiological and Pathological Conditions
CNS & Neurological Disorders - Drug Targets Synthesis of Kit-6 Magnetite Silica Nanocomposite Functionalized by Amine Group for Removal of Carmoisine Dye from Aqueous Solutions
Combinatorial Chemistry & High Throughput Screening Small Heat Shock Proteins and the Endoplasmic Reticulum: Potential Attractive Therapeutic Targets?
Current Molecular Medicine Editorial: Improving Neuropharmacology using Big Data, Machine Learning and Computational Algorithms
Current Neuropharmacology Microbial Biofilms: Impact on the Pathogenesis of Periodontitis, Cystic Fibrosis, Chronic Wounds and Medical Device-Related Infections
Current Topics in Medicinal Chemistry Determination of Human Serum α1-Acid Glycoprotein and Albumin Binding of Various Marketed and Preclinical Kinase Inhibitors
Current Medicinal Chemistry Glutamate and Schizophrenia: Pathophysiology and Therapeutics
Current Medicinal Chemistry - Central Nervous System Agents Attitudinal & Knowledge Barriers Towards Effective Pain Assessment & Management in Dementia: A Narrative Synthesis
Current Alzheimer Research Antiviral Sensing in Teleost Fish
Current Pharmaceutical Design The Potentials of Uncariae Ramulus Cum Uncis for the Treatment of Migraine: Targeting CGRP in the Trigeminovascular System
Current Neuropharmacology Recent Patents on Active Self-Ligating Brackets for Orthodontic Treatment
Recent Patents on Mechanical Engineering Gut Microbiome: Lactation, Childbirth, Lung Dysbiosis, Animal Modeling, Stem Cell Treatment, and CNS Disorders
CNS & Neurological Disorders - Drug Targets Microglial Senescence
CNS & Neurological Disorders - Drug Targets Protein Engineering of Bacterial Histidine Kinase Receptor Systems
Protein & Peptide Letters