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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Clinical Assessment of Cognitive Decline in Adults with Down Syndrome

Author(s): Marwan Sabbagh and Jamie Edgin

Volume 13, Issue 1, 2016

Page: [30 - 34] Pages: 5

DOI: 10.2174/1567205012666150921095724

Price: $65

Abstract

Down syndrome is an intellectual disability requiring periodic monitoring of cognition given the near universal presence of Alzheimer’s Disease related neuropathology and high rates of dementia in middle adulthood. We review current approaches to detecting decline in this population, including informant-based measures, dementia screening tools, and neuroimaging techniques. The challenges for detecting decline in this group are discussed, including the need to take into account premorbid cognitive function as well as medical comorbidity.

Keywords: Alzheimer’s disease, assessment, decline, dementia, down syndrome, neuropsychological, sleep.


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