A case of 64-year-old man was reported who carried to infection clinic with painful red rash affecting the right leg and hip for nearly one month. He had previously been treated with oral and intravenous broad-spectrum antibiotics but had not been recovered. A skin biopsy specimen observed marked edema of the upper dermis with a diffused inflammatory infiltrate of the upper dermis consisting mainly of neutrophils. Our patient was diagnosed with Sweet syndrome based on clinical appearance, laboratory investigations and histological findings. He consulted hematology clinic and a diagnosis of Multiple myeloma was made. We considered that physicians should be conscious of this subject, especially in skin lesions with fever because this may be a first sign of an underlying malignancy.
Keywords: Broad-spectrum antibiotics, cellulitis, multiple myeloma, paraneoplastic syndrome, splenomegaly, sweet syndrome.