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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

The Use of Biomarkers for Bladder Cancer Diagnosis and Surveillance

Author(s): Bernhard Grubmüller, Morgan Roupret, Alberto Briganti and Shahrokh F. Shariat

Volume 16, Issue 18, 2016

Page: [1444 - 1449] Pages: 6

DOI: 10.2174/1389557515666150909141404

Price: $65


Bladder cancer - a propensity that is associated with high recurrence and mortality rates. Various molecular alterations are reflected by diverse cellular morphological manifestations and vast tumor heterogeneity. Many biomarkers have been described that have undergone clinical trials and are approved for clinical use, but most still remain investigational. The question how molecular markers can support surveillance of different patient groups is still a matter of controversy. However, it can be expected that major advancement in the understanding of molecular pathways involved in urothelial carcinogenesis will enable improved patient management. The scope of this review is to discuss the established diagnostic tests and urinary biomarkers and their application for screening and surveillance of bladder cancer.

Keywords: Bladder cancer, Biomarkers, Cytology.

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