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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Synthesis of New Thiazole Derivatives as Antitumor Agents

Author(s): Eman M. H. Abbas, Sobhi M. Gomha, Thoraya A. Farghaly and Mohamed M. Abdalla

Volume 13, Issue 3, 2016

Page: [456 - 465] Pages: 10

DOI: 10.2174/1570179412666150828195202

Price: $65


New series of substituted thiazole were prepared starting from thiosemicarbazone derivatives 1a,b by reacting with different reagents namely, hydrazonoyl chlorides, dimethyl acetylene dicarboxylate, phenacyl bromide, chloroacetone, and chloroacetic acid. The structures of the newly synthesized compounds were elucidated on the basis of elemental analyses and spectral data. Some representative examples of the newly synthesized compounds were screened as antitumor agents against all the 60 cell lines of the NCI-60 cell panels. The tested compounds were active only against MCF7, SF268, SF295, HT29, HT29, COLO205, COLO205, K562, HL60, A549-ATCC, H460, LOXIMVI, OVCAR3, OVCAR4, OVCAR5, OVCAR8, SKOV3, PC39, DU145 and A498 while inactive against other cell lines in the panel.

Keywords: Thiazole, hydrazonoyl chlorides, thiosemicarbazone, antitumor activity.

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