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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Contributions on Kinetic Resolution by Lipases on the Development of Organic Synthesis in Brazil

Author(s): Leandro H. Andrade, Bruno A. Sousa, Irlon M. Ferreira and André L. M. Porto

Volume 12, Issue 6, 2015

Page: [696 - 713] Pages: 18

DOI: 10.2174/157017941206150828103404

Price: $65


In recent decades the need for new chiral compounds with high enantiomeric excesses has been rapidly emerging. Among the various methods used to achieve chiral compounds, one can highlight the enzymatic kinetic resolution of racemic esters, alcohols and amines and as the most versatile enzymatic methodology used in organic routes. Enzymes are used in biocatalytic routes to obtain enriched and enantiomerically pure compounds. The most remarkable biocatalysts for these processes are lipases, which have the capability of being used in organic media. Thus, the main purpose of this article was to present a review about studies conducted in Brazil involving the kinetic resolution of racemic compounds using lipases, also including unusual substrates containing heteroatoms, such as boron, silicon, selenium, tellurium and sulfur.

Keywords: Biocatalysis, Lipases, Candida antarctica, Immobilization, Kinetic Resolution.

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