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Recent Patents on Anti-Infective Drug Discovery


ISSN (Print): 1574-891X
ISSN (Online): 2212-4071

Methicillin-Resistant Staphylococcus aureus: Treatment with Cultures of Non Drug-Resistant Staphylococcus epidermidis

Author(s): Felix-Martin Werner and Rafael Covenas

Volume 10, Issue 2, 2015

Page: [124 - 127] Pages: 4

DOI: 10.2174/1574891X10666150827103448

Price: $65


The colonization and infection with methicillin-resistant Staphylococcus aureus is a major health problem in hospitals and long-term care facilities. Although bacteriaemias with MRSA (methicillin-resistant Staphylococcus aureus) can be treated with vancomycin and other reserve antibiotics, 20% of patients cannot be successfully cured. Inpatients colonized with MRSA are isolated in hospitals according to the guidelines of the Robert-Koch-Institute, although in long-term care facilities these patients are not urgently isolated. Active decolonization measures are taken to eradicate colonization with MRSA. In order to reduce MRSA colonization, it could be possible to administer cultures of Staphylococcus epidermidis which have no antibiotic resistance, so that physiological genes could be conferred from Staphylococcus epidermidis to MRSA bacteria.

Keywords: Bacteriaemia, colonization, daptomycin, extended spectrum ß-lactamase, methicillin-resistant Staphylococcus aureus, multi-resistance, Staphyloccus epidermidis, vancomyin.

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