Review Article

Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer

Author(s): Jan J. Melenhorst, Simon F. Lacey and Felipe Bedoya

Volume 18, Issue 3, 2017

Page: [332 - 340] Pages: 9

DOI: 10.2174/1389450116666150825120427

Price: $65


The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we describe the technological advances in the field of CARs and highlight critical components of its success. Additionally, we describe how various laboratories have worked toward developing new, safer, and more potent CARs for cancer.

Keywords: Cell therapy, chimeric antigen receptor (CAR), gene therapy, synthetic biology.

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