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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Exploring the Aldol Reaction in the Synthesis of Bioactive Compounds

Author(s): Marco A.B. Ferreira, Luiz C Dias, Ives A. Leonarczyk, Ellen C. Polo and Emílio C. de Lucca

Volume 12 , Issue 5 , 2015

Page: [547 - 564] Pages: 18

DOI: 10.2174/157017941205150821124901

Price: $65


Carbonyl chemistry, specifically aldol reactions, is one of the most efficient and elegant strategies to build carbon-carbon bonds. In the last 15 years in Brazil, our research group and others have worked on the development and application of stereoselective aldol reactions, with direct application in the asymmetric synthesis of several natural products of biological interest. In this review, we highlight the major Brazilian contributions to this field.

Keywords: Aldol Reactions, Stereoselectivity, total synthesis, natural products.

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