Abstract
This review deals with the important changes that have taken place in the last twenty to thirty years, on the directions and objectives of organic synthesis. Target oriented synthesis now competes with diversity oriented synthesis, and variations, in an attempt to occupy chemical space more completely. At the same time practicality, efficiency, scalability and robustness are once again the major goals to be associated with atom, step and function economies, within the context of sustainability.
Keywords: Continuous flow, diversity oriented synthesis, function oriented synthesis, new directions, practical efficient synthesis, target oriented synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Biorthogonal Chemistry: A translational chemical tool for in vivo applications
After the discovery in 1990, bioorthogonal chemistry encompassed a set of diverse fast-paced selective chemical reactions, facilitating the study of biomolecules under physiological aura without intervening in the biochemical processes. Over the past two decades, significant progress has been witnessed in bioorthogonal reactions such as Staudinger ligation, metal-catalyzed coupling reactions, ...read more
Design and Synthesis of Green Pesticides
The development of green new pesticides is currently one of the hotspots in the field of pesticide research, aiming to develop efficient, environmentally friendly, and safe pesticide products to meet the needs of modern agricultural production. Green new pesticides prioritize environmental friendliness and ecological safety. Therefore, during the research and ...read more
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Novel Green Approaches in the Synthesis of Bioactive Molecules
This special issue regards several aspects of green chemistry, focusing on innovative strategies to run organic synthesis reactions in a more environmentally friendly. Interesting articles or reviews about the critical role of green methodologies in reducing the environmental impact of chemical processes are welcome. Moreover, novel methodological studies using sustainable ...read more
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