Neuroprotective effects of the securinine-analogues: identification of Allomargaritarine as a lead compound

Title:Neuroprotective effects of the securinine-analogues: identification of Allomargaritarine as a lead compound

Volume: 15 Issue: 1

Author(s): Margarita E. Neganova, Sergei G. Klochkov, Svetlana V. Afanasieva, Tatiana P. Serkova, Ekaterina S. Chudinova, Sergei O. Bachurin, V. Prakash Reddy, Gjumrakch Aliev and Elena F. Shevtsova

Affiliation:

Keywords: Neurodegenerative diseases, neuroprotection, mitochondria, lipid peroxidation, antioxidant, alkaloids, lactones.

Abstract: Oxidative stress and mitochondrial disturbances are the common and important causative factors of aging, and play an important role in the late onset of sporadic neurodegenerative diseases, including Alzheimer disease (AD). Furthermore, emerging evidence from in vitro and in vivo disease models suggests that oxidative stress and increased vulnerability to induction of mitochondrial permeability transition leads to the pathogenesis of the neurological disorders. Towards the goals of developing effective neuroprotectors, this article describes the synthesis and neuroprotective studies of various derivatives of the naturally occurring alkaloid securinine, based on which a lead compound, allomargaritarine (a diastereomer of margaritarine), was identified as an effective therapeutic for neuroprotection. Allomargaritarine exhibits high antioxidant activity, and has significant mitoprotective effect on cellular models of neurodegeneration.

Cite this article as:

Neganova E. Margarita, Klochkov G. Sergei, Afanasieva V. Svetlana, Serkova P. Tatiana, Chudinova S. Ekaterina, Bachurin O. Sergei, Reddy Prakash V., Aliev Gjumrakch and Shevtsova F. Elena, Neuroprotective effects of the securinine-analogues: identification of Allomargaritarine as a lead compound, CNS & Neurological Disorders - Drug Targets 2016; 15(1) . https://dx.doi.org/10.2174/1871527314666150821111812