Abstract
A series of novel acetylated piperazine-containing N-glucosides and bis(Nglucoside) 8a-i were synthesized by the nucleophilic addition of acetylated glucopyranosyl isothiocyanate with various substituted piperazines in THF with high yields. Their novel deacetylated products 9a-i were also synthesized after Me- ONa/MeOH treatment. The preliminary bioassays for 18 novel title compounds showed that several compounds have significant fungicidal activity against Fusarium omysporum, Cercospora arachidicola and Phytophthora capsici at 50 μg/mL.
Keywords: N-Glucoside, substituted piperazine, glucopyranosyl isothiocyanate, synthesis, biological activity.
Letters in Drug Design & Discovery
Title:Synthesis and Biological Activity of Novel N-glucosides Containing Substituted Piperazine Moiety
Volume: 13 Issue: 4
Author(s): Li-Yuan Zhang, Bao-Lei Wang, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song and Zheng-Ming Li
Affiliation:
Keywords: N-Glucoside, substituted piperazine, glucopyranosyl isothiocyanate, synthesis, biological activity.
Abstract: A series of novel acetylated piperazine-containing N-glucosides and bis(Nglucoside) 8a-i were synthesized by the nucleophilic addition of acetylated glucopyranosyl isothiocyanate with various substituted piperazines in THF with high yields. Their novel deacetylated products 9a-i were also synthesized after Me- ONa/MeOH treatment. The preliminary bioassays for 18 novel title compounds showed that several compounds have significant fungicidal activity against Fusarium omysporum, Cercospora arachidicola and Phytophthora capsici at 50 μg/mL.
Export Options
About this article
Cite this article as:
Zhang Li-Yuan, Wang Bao-Lei, Zhan Yi-Zhou, Hua Xue-Wen, Liu Ming, Zhang Xiao, Song Hai-Bin and Li Zheng-Ming, Synthesis and Biological Activity of Novel N-glucosides Containing Substituted Piperazine Moiety, Letters in Drug Design & Discovery 2016; 13 (4) . https://dx.doi.org/10.2174/1570180812666150819003514
DOI https://dx.doi.org/10.2174/1570180812666150819003514 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Transglutaminase Activity as a Possible Therapeutical Target in Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Limitations of Current Antiretroviral Agents and Opportunities for Development
Current Pharmaceutical Design Cannabinoid Receptor Type 2 Activation in Atherosclerosis and Acute Cardiovascular Diseases
Current Medicinal Chemistry Meet Our Co-Editor
Current Psychopharmacology An Integrated and Disease-Oriented Growth Factor-Regulated Signal Transduction Network
Current Molecular Medicine Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents
Current Drug Targets Updates on Therapeutics in Clinical Trials for Spinal Cord Injuries: Key Translational Applications of Human Embryonic Stem Cells-Derived Neural Progenitors
CNS & Neurological Disorders - Drug Targets Enhanced Mechanical Properties of Rabbit Flexor Tendons in Response to Intratendinous Injection of Adipose Derived Stromal Vascular Fraction
Current Stem Cell Research & Therapy CoMFA and CoMSIA Analyses of Highly Selective Pipecolic Acid Based TNF-α Converting Enzyme (TACE) Inhibitors Using Docked Conformations for Molecular Alignment
Letters in Drug Design & Discovery 3D-QSAR and in-silico Studies of Natural Products and Related Derivatives as Monoamine Oxidase Inhibitors
Current Neuropharmacology School-Based Cognitive Behavioral Therapy: Current Status and Alternative Approaches
Current Psychiatry Reviews Assessment of Chemosensory Function Using “Sniffin’ Sticks”, Taste Strips, Taste Sprays, and Retronasal Olfactory Tests
Current Pharmaceutical Design Co-Morbidity of APD and Reading Disabilities
Current Pediatric Reviews Tyrphostins as Potential Therapeutic Agents for Acute Kidney Injury
Current Medicinal Chemistry Efficient and Environmentally Benign Diversity Oriented Synthesis of 2, 3- dihydroquinazolin-4(1H)-ones Using GAAS As a Bio-based Green Solvent
Current Green Chemistry Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias
Current Cardiology Reviews Phenolic Compounds in Prevention and Treatment of Skin Cancers: A Review
Current Medicinal Chemistry MicroRNAs and Cancer; an Overview
Current Pharmaceutical Biotechnology Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Child Mental Health in the Philippines
Adolescent Psychiatry