Abstract
This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infectious diseases.
Keywords: β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis.
Current Organic Synthesis
Title:Natural Naphthoquinones with Great Importance in Medicinal Chemistry
Volume: 13 Issue: 3
Author(s): Fernando de Carvalho da Silva and Vitor Francisco Ferreira
Affiliation:
Keywords: β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis.
Abstract: This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infectious diseases.
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Cite this article as:
de Carvalho da Silva Fernando and Francisco Ferreira Vitor, Natural Naphthoquinones with Great Importance in Medicinal Chemistry, Current Organic Synthesis 2016; 13 (3) . https://dx.doi.org/10.2174/1570179412666150817220343
DOI https://dx.doi.org/10.2174/1570179412666150817220343 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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